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Columbia University's online course on stem cells offers the following definitions of hybrids and chimeras (in quotes):
"A hybrid is created when an ovum from one species is fertilized by the sperm of another species. All the cells in a hybrid organism contain the same genetic information that is derived from the two different species." In other words, a hybrid organism can be created via sexual reproduction (ovum + sperm).
"[H]uman-animal chimeras, generated by introducing human stem cells into an animal embryo, are composed of two genetically distinct types of cells. One cell type contains a complete human genome while the second cell type contains a complete genome of the animal species." Inter-species chimeras cannot occur in nature, but must be created in a lab.
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